IDENTIFICATION OF DEUBIQUITINASE INHIBITORS VIA HIGH-THROUGHPUT SCREENING USING A FLUOROGENIC UBIQUITIN-RHODAMINE ASSAY

Identification of deubiquitinase inhibitors via high-throughput screening using a fluorogenic ubiquitin-rhodamine assay

Summary: Identification of selective deubiquitinase (DUB) inhibitors is critical for probe development to further cashel tail bag understand and explore DUB biological function.Here, we detail the optimization and deployment of an in vitro fluorogenic ubiquitin-rhodamine assay to conduct high-throughput screening of a small molecule library against

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Automated Geolocation in Urban Environments Using a Simple Camera-Equipped Unmanned Aerial Vehicle: A Rapid Mapping Surveying Alternative?

GNSS positioning accuracy can be degraded in areas where the surrounding object geometry and morphology interacts with the GNSS signals.Specifically, urban environments sofia barclay sexy pose challenges to precise GNSS positioning because of signal interference or interruptions.Also, non-GNSS surveying methods, including total stations and laser s

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The Influence of Osmotic Stress on Physiological and Biochemical Indices at Garlic (Allium sativum L.) Local Populations

Garlic is an asexually propagated crop with high morphological diversity and uses throughout the world.Although the salt tolerance among the cultivated species is low, there are some genotypes which present an acceptable level of adaptability to moderate saline conditions.In vegetables, these genotypes are represented especially by local varieties

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